Kansas State rallied from a 3-0 deficit to beat Colorado 4-3 in Manhattan.
Colorado's tennis team will hit the road for the next month starting this weekend with matches at Kansas State and Kansas.
Tina Bokhua became the first CU tennis player to be named Pac-12 Player of the Week on Monday.
CU recovered from a tight loss on Saturday with a 7-0 win over Boise State on Sunday.
Colorado fell 4-3 to No. 69 Denver after trailing 3-0 in the match.
Colorado will host the University of Denver and Boise State at the Rocky Mountain Tennis Center in Boulder on Saturday and Sunday.
Live results for Colorado vs. Boise State - 1/31/16
Colorado swept doubles for the first time this season and defeated UTEP 5-2 on Sunday.
Colorado's comeback came up just short as No. 64 New Mexico held off the Buffs 5-2 in Albuquerque.
CU's tennis team will play two matches in Albuquerque this weekend, facing New Mexico on Friday and UTEP on Sunday.
Colorado's tennis team swept singles competition on Sunday for a 6-1 win over Air Force to open the spring season.